ADURO BIOTECH, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
Thomas W. Dubensky, JR.,David B. Kanne,Meredith Lai Ling Leong,Edward Emile Lemmens,Laura H. Glickman,Russell E. Vance
申请号：
US15665378
公开号：
US20170333552A1
申请日:
2017.07.31
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are substantially pure 2′,5′,2′,5′ and 2′,5′,3′,5′ CDNs, and preferably Rp,Rp stereoisomers thereof.
