Aduro Biotech, Inc.;The Regents of the University of California
发明人:
DUBENSKY, Thomas,KANNE, David,LEONG, Meredith,GLICKMAN, Laura,VANCE, Russell,LEMMENS, Edward
申请号：
LT14800848
公开号：
LT2996473T
申请日:
2014.05.18
申请国别(地区):
LT
年份:
2019
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are substantially pure 2′,5′,2′,5′ and 2′,5′,3′,5′ CDNs, and preferably Rp,Rp stereoisomers thereof.
