Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling

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专利权人:

发明人:

Thomas W. Dubensky, Jr.,David B. Kanne

申请号：

US14280668

公开号：

US09549944B2

申请日:

2014.05.19

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention provides cyclic-di-nucleotide (CDN) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides which inhibit STING-dependent TBK1 activation and the resulting production of type I interferon.

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