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Polymer conjugate of taxane
专利权人:
Masayuki Kitagawa
发明人:
Masayuki Kitagawa,Keizou Ishikawa,Takeshi Onda
申请号:
US12225230
公开号:
US08323669B2
申请日:
2007.03.22
申请国别(地区):
US
年份:
2012
代理人:
摘要:
[Problems] To provide a novel taxane derivative which can release the medicinal substance in a bioenzyme-independent manner, is expected to have an effective therapeutic efficacy, and has a water-solubility.[Means for Solving Problems] Disclosed is a polymer conjugate of a taxane, which comprises a polymer having a polyethylene glycol moiety and two or more succinic acid monoamide moieties and a taxane, wherein a carboxylate group in the polymer and an alcoholic hydroxyl group in the taxane are bound to each other via an ester bonding.
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