WANG WEIBO,BARSANTI PAUL A,XI YI,BOYCE RUSTUM S,PECCHI SABINA,BRAMMEIER NATAHAN,PHILLIPS MEGAN,MENDENHALL KRIS,WAYMAN KELLY,LAGNITON LIANA MARIE
申请号：
IN144/KOLNP/2007
公开号：
IN253477B
申请日:
2007.01.11
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
This invention is directed to substituted imidazole compounds which modulate the activity of KSP and are useful for the treatment of cancer and are represented by the formula (I) wherein: R1 is selected from the group consisting of aminoacyl, acylamino, carboxyl, carboxyl ester, aryl, and alkyl optionally substituted with hydroxy or halo R2 is selected from the group consisting of hydrogen, alkyl, and aryl R3 is selected from the group consisting of hydrogen and -X-A, wherein X is selected from the group consisting of-C(O)-, -C(S)-, -S(O)-, -S(O)2, and -S(O)2-N(R)-, where R is hydrogen or alkyl and A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents R5 is selected from the group consisting of L-A1, wherein L is selected from the group consisting of-S(O)q- where q is one or two, and C1 to C5 alkylene optionally substituted with hydroxy, halo, or acylamino and A1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, and substituted cycloalkyl and one of either R6 or R7 is selected from the group consisting of heterocyclic, aryl and heteroaryl, all of which may be optionally substituted with -(R8)m where R8 is as defined herein and m is an integer from 1 to 3, and the other Of R6 or R7 is selected from the group consisting of hydrogen, halo, and alkyl or R6 and R7 are both hydrogen the other substituents are defined in the claims.
