A compound having Formula I-A: ** (See formula) ** or a pharmaceutically acceptable salt or solvate thereof, wherein: R1 is hydrogen, OH, halo, cyano, carboxy, or aminocarbonyl； or alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, or alkynyloxy, any of which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, halo, haloalkyl, amino, alkylamino, dialkylamino , carboxy, alkoxy, alkoxycarbonyl, aryl, heteroaryl, heterocycle, cycloalkyl, and cycloalkenyl, wherein the aryl, heteroaryl, heterocycle, cycloalkyl, and cycloalkenyl are optionally substituted with 1, 2, or 3 independently selected R11a groups； R2 is: (a) hydrogen or carboxamide； or (b) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, (cycloalkyl) alkyl, (cycloalkenyl) alkyl, (heterocycle) alkyl, arylalkyl, heteroarylalkyl, alkylcarbonyl, alkoxycarbonyl, (arylalkoxy) carbonyl, or ( heteroarylalkoxy) carbonyl, any of which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, alkyl, halo, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl, aryl , heteroaryl, heterocycle, cycloalkyl, and cycloalkenyl, wherein the aryl, heteroaryl, heterocycle, cycloalkyl, and cycloalkenyl are optionally substituted with 1, 2, or 3 independently selected R11a groups； R3 is hydrogen, OH, or halo； or alkoxy, alkylamino, or dialkylamino, any of which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxyl, halo, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl , aryl, heteroaryl, heterocycle, cycloalkyl, and cycloalkenyl, wherein the aryl, heteroaryl, heterocycle, cycloalkyl, and cycloalkenyl are optionally substituted with 1, 2, or 3 independently selected R11a groups； R4a1 is selected from the group consisting of C3-C6 alkyl, arylalkyl, (cycloalkyl) alk
