METHODS AND COMPOSITIONS FOR THE SUPPLY OF ARYL SULPHATASE A

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专利权人:

Inc.;Shire Human Genetic Therapies

发明人:

SALAMAT-MILLER, Nazila,TAYLOR, Katherine,CAMPOLIETO, Paul,SHAHROKH, Zahra,PAN, Jing,CHARNAS, Lawrence,WRIGHT, Teresa Leah,CALIAS, Pericles

申请号：

DK11799037

公开号：

DK2585104T3

申请日:

2011.06.25

申请国别(地区):

DK

年份:

2019

代理人:

摘要：

The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/