METHODS AND COMPOSITIONS FOR CNS DELIVERY OF B-GALACTOCEREBROSIDASE

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专利权人:

Shire Human Genetic Therapies; Inc.

发明人:

Nazila Salamat-Miller,Katherine Taylor,Ken Manning,Gaozhong Zhu,Paul Campolieto,Zahra Shahrokh,Pericles Calias,Thomas McCauley

申请号：

US13862187

公开号：

US20130295071A1

申请日:

2013.04.12

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an B-Galactocerebrosidase protein, salt, and a polysorbate surfactant for the treatment of GLD Disease.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/