METHODS AND COMPOSITIONS FOR CNS DELIVERY OF ARYLSULFATASE A

• 收藏
• 分享

专利权人:

Nazila Salamat-Miller;Lawrence Charnas;Pericles Calias;Zahra Shahrokh;Jing Pan;Paul Campolieto;Katherine Taylor;Teresa Leah Wright

发明人:

Nazila Salamat-Miller,Katherine Taylor,Paul Campolieto,Zahra Shahrokh,Jing Pan,Lawrence Charnas,Teresa Leah Wright,Pericles Calias

申请号：

US13168963

公开号：

US20120009171A1

申请日:

2011.06.25

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/