METHODS AND COMPOSITIONS FOR CNS DELIVERY OF ARYLSULFATASE A

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专利权人:

Inc.;Shire Human Genetic Therapies

发明人:

Pan, Jing,Charnas, Lawrence,Wright, Teresa Leah,Calias, Pericles,Salamat-Miller, Nazila,Taylor, Katherine,Polieto, Paul,Shahrokh, Zahra

申请号：

AU2019204051

公开号：

AU2019204051A1

申请日:

2019.06.11

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

#$%^&*AU2019204051A120190829.pdf#####ABSTRACT The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/