Methods and compositions for CNS delivery of arylsulfatase A

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专利权人:

Inc.;Shire Human Genetic Therapies

发明人:

Salamat-Miller, Nazila,Taylor, Katherine,Campolieto, Paul,Shahrokh, Zahra,Pan, Jing,Charnas, Lawrence,Wright, Teresa Leah,Calias, Pericles

申请号：

AU2011270670

公开号：

AU2011270670B2

申请日:

2011.06.25

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/