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Phosphate produced by sugarcane compounds used to treat viral infections
专利权人:
UNIVERSITY COLLEGE OF CARDIFF CONSULTANTS LIMITED;INHIBITEX, INC.
发明人:
CHAMBERLAIN, STANLEY,HUTCHINS, JEFF,VERNACHIO, JOHN,MADELA, KAROLINA,MCGUIGAN, CHRISTOPHER,ALJARAH, MOHAMED,GILLES, ARNEUD
申请号:
PE2011001334
公开号:
PE20120013A1
申请日:
2010.01.11
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
1. A.1. A. is phenyl, naphthalene and others; X is s, NH and O; R1 is asphalt (C1-C6);Chlorinated or arilo (c0-c6) asphalt; R2 is h, phenyl, arilo or arilo (c0-c6) asphalt; R3 is h and oh; R4 and R5 are each h, pitch (C1-C6) is optionally replaced by pitch or phenyl; R6 is pitch (C1-C10),Bicycle (c3-c8),Among other things The most popular compounds are: benzenebis (s) ((2R, 3R, 4R, 5R) - 5 - (2-amino-6-methyl-9h-purin-9-il) - 3, 4-dihydroxi-4-methylfuran-2-il) eleven (naftelen-1-iloxi) phosphoramide) propane; 2, 4-diffluenobencil 2 (s) ((2R, 3R, 4R, 5R) - 5 - (2-9-9-3-9-7) 4-dihydroxi-4-methyltetrahydrofuran-2-il-methoxy (naftelen-1-iloxi) phosphate amine-3-methylbutyrate, etc. He also mentioned a pharmaceutical composer These compounds are N5B polymerase inhibitors of hexachlorobenzene and are useful tools for the treatment of hepatitis C infection.SE REFIERE A COMPUESTOS DERIVADOS FOSFORAMIDATOS DEL NUCLEOSIDO GUANOSINA DE FORMULA (I) DONDE Ar ES FENILO, NAFTILO, ENTRE OTROS; X ES S, NH Y O; R1 ES ALQUILO(C1-C6), BENCILO O ARILO(C0-C6)ALQUILO; R2 ES H, FENILO, ARILO O ARILO(C0-C6)ALQUILO; R3 ES H Y OH; R4 Y R5 SON CADA UNO H, ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON ALQUILTIO, O FENILO; R6 ES ALQUILO(C1-C10), CICLOALQUILO(C3-C8), INDANILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: BENCILO 2(S)-((((2R,3R,4R,5R)-5-(2-AMINO-6-METOXI-9H-PURIN-9-IL)-3,4-DIHIDROXI-4-METILTETRAHIDROFURAN-2-IL)METOXI(NAFTALEN-1-ILOXI)FOSFORILAMINO)PROPANOATO; 2,4-DIFLUOROBENCIL 2(S)-((((2R,3R,4R,5R)-5-(2-AMINO-6-METOXI-9H-PURIN-9-IL)-3,4-DIHIDROXI-4-METILTETRAHIDROFURAN-2-IL)METOXI(NAFTALEN-1-ILOXI)FOSFORILAMINO)-3-METILBUTANOATO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA POLIMERASA NS5B DEL VHC SIENDO UTILES EN EL TRATAMIENTO DE LA INFECCION POR HEPATITIS C
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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