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CETP inhibitors for fusion nitrogen dioxide
专利权人:
MERCK SHARP AND DOHME CORP.
发明人:
SHAO, PENGCHENG PATRICK,YE, FENG,VACHAL, PETR,SHA, DEYOU,KATIPALLY, REVATHI REDDY,LIU, JIAN,SUN, WANYING
申请号:
PE2014000616
公开号:
PE20141230A1
申请日:
2012.10.25
申请国别(地区):
PE
年份:
2014
代理人:
摘要:
It refers to the nitrous oxide compound of fusion (I), wherein R1 is h, asphalt (C1-C5),Halogen, among others; X is 0 or 1; dotted line represents optional double link; D1 is n or CR2; D2 is n or CR3; D3 is n or Cr4, where R2, R3 and R4 are h, tar (C1-C5), respectively,O-asphalt (C1-C5),Alquenilo(C2-C5),R5 is an asphalt (C1-C5), among other things,Bitumen (C2-C5),1. Halogen, A1 is phenyl, cyclomethane (c3-c8), among others,A2 is phenyl, among other things; a is 0 to 3. - trifluoro (trifluoro-1-1-1-1-1-1-1-trifluoro-1-1 - (trifluoro-1 - (trifluoro-h-pirrolo [1, 2-C] [1, 3. Propane, including, inter Alia, [3] oxazol-5-il} - 6-methoxi-4 '- (trifluoroectane sulfonic acid) diphenyl-3-il; He also mentioned a pharmaceutical composer These compounds are inhibitors of cholesterol cholesterol (CETP) transfer proteins and are useful in the treatment of defatted, pathogenic sclerosis.SE REFIERE A COMPUESTOS DERIVADOS DE OXAZOLIDINONA BICICLICO FUSIONADO DE FORMULA (I) DONDE R1 ES H, ALQUILO(C1-C5), HALOGENO, ENTRE OTROS; x ES 0 O 1; LAS LINEAS DISCONTINUAS REPRESENTAN UN DOBLE ENLACE OPCIONAL; D1 ES N O CR2; D2 ES N O CR3; D3 ES N O CR4, EN DONDE R2, R3 Y R4 SON CADA UNO H, ALQUILO(C1-C5), O-ALQUILO(C1-C5), ALQUENILO(C2-C5), ENTRE OTROS; R5 ES ALQUILO(C1-C5), ALQUINILO(C2-C5), HALOGENO, ENTRE OTROS; A1 ES FENILO, CICLOALQUILO(C3-C8), ENTRE OTROS; A2 ES FENILO, ENTRE OTROS; a ES DE 0 A 3. SON COMPUESTOS PREFERIDOS: 3-[2'-{(1R,5S,7aS)-1-[3,5-BIS(TRIFLUOROMETIL)FENIL]-3-OXOTETRAHIDRO-1H-PIRROLO[1,2-c][1,3]OXAZOL-5-IL}-6-METOXI-4'-(TRIFLUOROMETIL)BIFENIL-3-IL]PROPANOATO DE METILO; ACIDO 3-[2'-{(1R,5S,7aS)-1-[3,5-BIS(TRIFLUOROMETIL)FENIL]-3-OXOTETRAHIDRO-1H-PIRROLO[1,2-c][1,3]OXAZOL-5-IL}-6-METOXI-4'-(TRIFLUOROMETIL)BIFENIL-3-IL]PROPANOICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA DE TRANSFERENCIA DE ESTERES DE COLESTEROL (CETP) SIENDO UTILES EN EL TRATAMIENTO DE DISLIPIDEMIA, ATEROSCLEROSIS
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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