Refers to compounds derived from 17? - alkyl - 17? - Oxy - estratrienos of formula (i) where Hal is Fluorine or Chlorine R1, R2 and R4 are each h, Fluorine, Chlorine or Bromine R3 is H, alkyl (c1-c4) or alcanilo (c1-c4) R17 is H, alkyl (c1-c4) or alcanilo (C1 - C4) R17 is alkyl (c1-c4), alquenilo (c2-c4) or alquinilo (c2-c4) or is alquileno (C1, C2 alquenileno (C13) - C13)Among others, V is methylene or - C (o) - X is a link or alquileno (C1 - C3) and is alquileno (C5 - C8) E (C1 - C4) or Perfluoroalkyl phenyl substituted by Halogen or Cf3 R5 is H, alkyl (c1-c4), alquenilo (c2-c4), among others r1 R6 h, or CH2 - C (o) - Where R1, R1 is H, alquenilo (C2 - C6), among others.Preferred compounds are: [5 - (11? Fluoro - 3.17? Dihydroxy - 17? - metilestra - 1,3,5 - (10) - triennium 2008-2010 7? IL) Pentyl] - (methyl) Amine (8,8,9,9,9 - pentafluorononil) 11. Fluoro - 17? - methyl - 7? - [5 - [(2R) - 2 - (7,7,8,8,8 - pentafluorooctil) - 1 - pirrolidinil) Pentyl] - 1,3,5 estra - (10) - 3:17 - Sledging? Diol among others. It also relates to a Pharmaceutical composition.These compounds are antiestrogenic action being useful in the treatment of Hormone dependent Tumors, Diffuse alopecia, endometriosisSE REFIERE A COMPUESTOS DERIVADOS DE 17?-ALQUIL-17?-OXI-ESTRATRIENOS DE FORMULA (I) DONDE HAL ES FLUOR O CLORO R1, R2 Y R4 SON CADA UNO H, FLUOR, CLORO O BROMO R3 ES H, ALQUILO(C1-C4) O ALCANILO(C1-C4) R17 ES H, ALQUILO(C1-C4) O ALCANILO(C1-C4) R17 ES ALQUILO(C1-C4), ALQUENILO(C2-C4) O ALQUINILO(C2-C4) U ES ALQUILENO(C1-C13), ALQUENILENO(C2-C13), ENTRE OTROS V ES METILENO O -C(O)- X ES UN ENLACE O ALQUILENO(C1-C3) Y ES ALQUILENO(C5-C8) E ES PERFLUOROALQUILO(C1-C4) O FENILO SUSTITUIDO CON HALOGENO O CF3 R5 ES H, ALQUILO(C1-C4), ALQUENILO(C2-C4), ENTRE OTROS R6 ES H, CH2-R1 O C(O)-R1, EN DONDE R1 ES H, ALQUENILO(C2-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: [5-(11?-FLUORO-3,17?-DIHIDROXI-17?-METILESTRA-1,3,5(10)-TRIEN-7?-IL)PENTIL](METIL)(8,8,9,9,9-PENTAFLUORONONIL)AMINA 11?-FLUORO
