GRICE, Cheryl A.,WEBER, Olivia D.,BUZARD, Daniel J.,SHAGHAFI, Michael B.,JONES, Todd K.
申请号：
PE2020000296
公开号：
PE20200664A1
申请日:
2018.08.28
申请国别(地区):
PE
年份:
2020
代理人:
摘要：
The present invention relates to compounds of hexafluoropropane diazo [4.5] decan carboxilato and hexafluoropropane piperidin carboxilato de Formos (III) derivatives,（i）(II) and (IV),And acceptable solutions, hydrates, ceramics, esters, positive oxidants and salts thereof, of which: (1) formula compound (III),x ES-CH2-O-C（O）-；This is a link, C1-C6 tar, C1-C6 halotar or c3-c8 ring； R1 and R2 are h or C1-C6 tar； R3 is a 5-to-6-member heteromorphic ring, or a 9-10 optional double ring heterocyclic ring, replaced by 1-3 R4, R4 is C1-C6 tar, halogenated, etc.； n is 0 or 1 and m are 1 or 2 when they are 0, M is 2 when n is 1 and M is 1,x ES-CH2-O-C（O）-；R1 and R2 are C1-C6 tar； R3 is a heteromorphic ring with 5 to 6 members or 9 to 10 members of a bicycle shaped ring, which can be replaced by 1 to 3 R4, where R4 is C1-C6 tar, halogen, etc.； n is 0 or 1, M is 1 or 2, n is 0, m is 2, n is 1, M is 1； III is formula compound (II),And es-ch2 O-C (o) -；Z is cyclo C3-C6； R3 is a special-shaped ring with 5-6 members or 9-10 selective non bicycle rings, replaced by 1-3 R4, where R4 is C1-C6 asphalt, halogen, etc.； R11 is h, C1-C6 asphalt or C1-C6 asphalt； R12 is C1-C6, R13 is h or C1-C6 asphalt, or C1-C6 is c1-c0 or c1-c1-c1 for C1-C6. （4） In formula compound (IV), the,X is a link, - C (o) - O-S (o) 2 -；R1 is C1-C6, C1-C6 halides and other substitutes, and the substitutes are 1-3 R2, wherein R2 is halide, C1-C6 or C1-C6 halide； R3 is h, C1-C6 asphalt, etc. The most popular compound is formula a,B，（c）D，There are others He also mentioned a pharmaceutical composer These compounds are MAGL modulators for the treatment of neuralgia, inflammation, etc.La presente invencion se refiere a compuestos derivados de hexafluoropropan-diazaespiro[4.5]decan-carboxilato y hexafluoropropan-piperidin-carboxilato de formulas (III), (I), (II) y (IV), y a sus solvatos, hidratos, tautomeros, esteroisomeros, N-oxidos y sales farmaceutica aceptables, donde: i) En el compuesto de formula (III), X es -CH2- o
