GRICE, Cheryl A.,WEBER, Olivia D.,BUZARD, Daniel J.,SHAGHAFI, Michael B.
申请号：
PE2020000297
公开号：
PE20200665A1
申请日:
2018.08.28
申请国别(地区):
PE
年份:
2020
代理人:
摘要：
The present invention refers to the formulated helical compound (I),（i'，Page: 1（iii）（iv）（vi）（v）（v'，（vii），(VIII) and its acceptable solutions, hydrates, taufroths, steroids, positive oxidants and pharmaceutical salts, wherein:And es-ch2-o-c (o) -；R1 and R2 are h or C1-C6 tar； R3 is C1-C6 tar, halogen, etc.； R4 is - c12-c6-co2h tar and c3-c8-co2h epoxy ethane； W is 0-4； N and m are 0-1； P and Q are 0-2, q is 0-0, P is 2； II is formula compound (I '),This is - CH2-R1 and R2 are h or C1-C6 tar； R3 is C1-C6 and halogen tar； R4 is - piperazin-ch2-co2h, - (2.5-diazabiciclo [2.2.1] heptone) - ch2-co2h, among others； W is 0-4； N and m are 0-1； P and Q are 0-2, q is 0-2； III is compound (II),And es-ch2-o-c (o) -；R3 is the tar of C1-C6, C1-C6 alquenio, C1-C6, etc.； P is 0-5； IV) compound (III),And es-ch2-o-c (o) -；R3 is the tar of C1-C6, C1-C6 alquenio, C1-C6, etc.； P is 0-5； V) formula compound (IV),R1 and R2 are h or C1-C6 tar； R3 is C1-C6 tar, C1-C6 alquenio, C1-C6 tar, etc.； P is 0-5； n is 0 or 1； m is 1 or 2； n is 0, M is 2, n is 1, M is 1； VI is formula compound (VI),R3 is the tar of C1-C6, C1-C6 alquenio, C1-C6； VII) compound (V),x ES-O-O-N（R11）-；R1 is h or C1-C6 tar； R2 is C1-C6 tar； R3 is C1-C6 tar, alquenio C2-C6, etc.； R11 is h, C1-C6 tar, etc.； P is 0-5, V is 0 or 1； VIII is compound (V '),x ES-O-O-N（R11）-；R1 is h or C1-C6 tar； R2 is C1-C6 tar； R3 is C1-C6 tar, halogen, etc.； R4 is - piperazin-ch2-co2h, - (2.5-diazabiciclo [2.2.1] heptone) - ch2-co2h, among others； R11 is h or C1-C6 tar； P is 0-4； V is 0 or 1； IX is compound (VII),R1 is octabromodiphenyl ether [3,4-c] piro-r6, where R6 is C1-C6 tar, etc.； R2 is C1-C6 tar, halide, etc.； P is 0-4； q is 1 or 2； X is compound (VIII),R1 is octabromodiphenyl ether [3.4-c] piro-r6, where R6 is, among other things, C1-C6 tar； R2 is C1-C6 tar, halogen, etc.； P is 0-4. The preferred compound is compound A,B，（c）D，There are others He also mentioned a pharmaceutical composer These compounds are MAGL modulators for the treatment
