JAROSKOVA, LIBUSE,LINDERS, JOHANNES,BUYCK, CHRISTOPHE,VAN DER VEKEN, LOUIS,DIMITROV, VLADIMIR,NIKIFOROV, THEO
申请号：
ES05747202
公开号：
ES2525319T3
申请日:
2005.04.29
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound for use as a medicine having the formula ** Formula ** a pharmaceutically acceptable addition salt or a stereochemical isomeric form thereof, in which n is 1 or 2； L represents a C1 connector substituted with 1 or 2 C1-4 alkyls； M represents a direct bond or a C1-3 alkanediyl linker optionally substituted with 1 or 2 substituents selected from hydroxy, C1-4 alkyl or C1-4 alkyloxy； R1 and R2 each independently represent hydrogen, halogen, cyano, hydroxy, C1-4 alkyl optionally substituted with halogen, C1-4 alkyloxy optionally substituted with one or whenever possible 2 or 3 substituents selected from hydroxy, Ar1 and halogen； or R1 and R2 considered together with the phenyl ring to which they are attached form naphthyl or 1,3-benzodioxolyl, wherein said naphthyl or 1,3-benzodioxolyl are optionally substituted with halogen； R3 represents hydrogen, halogen, C1-4 alkyl, C1-4 alkyloxy, cyano or hydroxy； R 4 represents hydrogen, halogen, C 1-4 alkyl, C 1-4 alkyloxy, cyano or hydroxy； R5 represents hydrogen, C1-4 alkyl or Ar2-C1-4 alkyl； R 6 represents hydrogen, halogen, C 1-4 alkyl or C 1-4 alkyloxy； Ar1 and Ar2 each independently represents phenyl or naphthyl, wherein said phenyl and naphthyl are optionally substituted with C1-4 alkyl, C1-4 alkyloxy or phenyl (C1-4) alkyl.Un compuesto para usar como una medicina que tiene la fórmula**Fórmula** una sal de adición farmacéuticamente aceptable o una forma isómera estereoquímica del mismo, en la que n es 1 o 2； L representa un conector C1 sustituido con 1 o 2 alquilos C1-4； M representa un enlace directo o un conector alcanodiilo C1-3 opcionalmente sustituido con 1 o 2 sustituyentes seleccionados de hidroxi, alquilo C1-4 o alquiloxi C1-4； R1 y R2 cada uno independientemente representa hidrógeno, halógeno, ciano, hidroxi, alquilo C1-4 opcionalmente sustituido con halógeno, alquiloxi C1-4 opcionalmente sustituido con uno o cuando sea posible 2 o 3 sustituyentes seleccionados de hidroxi, Ar1 y halógeno； o R1 y R2 cons
