Hans HILPERT,Sabine KOLCZEWSKI,Anja LIMBERG,Theodor STOLL
申请号：
MX2016014845
公开号：
MX2016014845A
申请日:
2015.05.19
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
The present invention is concerned with indolin-2-one and l,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives of general formula (I) wherein Ar1 is phenyl, pyridinyl or pyrimidinyl Ar2 is a 5 or 6 membered heteroaryl group, containing 2 or 3 heteroatoms, selected from N, O or S R1 is hydrogen, lower alkyl, halogen or lower alkoxy R2 is hydrogen or lower alkyl R3 is hydrogen, lower alkyl, lower alkyl substituted by hydroxy, cycloalkyl, oxetan-3-yl, pyridinyl, imidazolyl, pyrazolyl, pyrimidinyl, which rings may optionally substituted by lower alkyl, or is -(CH2)3-S(O)2-cyclopropyl X is CH or N n is 1 or 2 as well as with a pharmaceutically acceptable salts thereof, with a racemic mixture, or with its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof, for use in the treatment of certain central nervous system disorders which are positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimers disease, autism, Parkinsons disease, chronic pain, borderline personality disorder, sleep disturbances, chronic fatigue syndrome, stiffness, antiinflammatory effects in arthritis and balance problems.La presente invención se refiere a los derivados indolin-2-ona y 1,3-dihidro-pirrol [3,2-c] piridin-2-ona de fórmula general: (ver Fórmula) en donde Ar1 es fenilo, piridinilo o pirimidinilo, Ar2 es un grupo heteroarilo de 5 o 6 elementos, que contiene 2 o 3 heteroátomos, seleccionado de entre N, O o S, R1 es hidrógeno, alquilo inferior, halógeno o alcoxi inferior, R2 es hidrógeno o alquilo inferior, R3 es hidrógeno, alquilo inferior, alquilo inferior sustituido con hidroxi, cicloalquilo, oxetan-3-ilo, piridinilo, imidazolilo, pirazolilo, pirimidinilo, los anillos de los cuales pueden sustituirse opcionalmente con alquilo inferior, o es -(CH2)3-S(O)2-cicl
