KONDRU, RAMA K.,LOU, YAN,SJOGREN, ERIC BRIAN,SOTH, MICHAEL
申请号：
ES09780304
公开号：
ES2461494T3
申请日:
2009.07.08
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula I, or II ** Formula ** in which: R is -R1-R2-R3, or -R1-R3； R1 is phenyl or pyridyl, and is optionally substituted with R1； wherein R 1 'is C 1-6 alkyl, hydroxy, C 1-6 hydroxyalkyl, C 1-6 alkoxy, halogen, nitro, amino, cycloalkyl, heterocycloalkyl, cyano, or C 1-6 haloalkyl； R2 is -C (>； = O), -C (>； = O) O, -C (>； = O) N (R2 '), - (CH2) q, or -S (>； = O) 2； wherein R2 'is H or C1-6 alkyl； and q is 1, 2 or 3； R3 is H or R4； wherein R 4 is C 1-6 alkyl, C 1-6 alkoxy, amino, aryl, arylalkyl, alkylaryl, heteroaryl, alkyl heteroaryl, heteroaryl alkyl, cycloalkyl, alkyl cycloalkyl, cycloalkyl alkyl 15, heterocycloalkyl, alkyl heterocycloalkyl, or heterocycloalkyl alkyl, and is optionally substituted with one or more C 1-6 alkyl, hydroxy, oxo, C 1-6 hydroxyalkyl, C 1-6 alkoxy, halogen, nitro, amino, cyano, C 1-6 alkylsulfonyl, or C 1-6 haloalkyl； Q in formula I is CH or N； in formula II it is CH2, CH (Y ') or NH； wherein Y 'is halogen, hydroxy, or C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-6 alkoxy, amino, and halogen ； each Y1 is independently Y1a or Y1b； in which Y1a is halogen； and Y1b is C1-6 alkyl, optionally substituted with one or more Y1b '； wherein Y1b 'is hydroxy, C1-6 alkoxy, or halogen； n is 0, 1, 2 or 3； Y2 is Y2a or Y2b； wherein Y2a is H or halogen； and Y2b is C1-6 alkyl, optionally substituted with one or more Y2b '； wherein Y2b 'is hydroxy, C1-6 alkoxy, or halogen； Y3 is halogen or C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-6 alkoxy, amino, and halogen； m is 0 or 1； Y4 is Y4a, Y4b, Y4c, or Y4d； wherein Y4a is H or halogen； Y4b is C1-6 alkyl, optionally substituted with one or more substituents selected from the group consisting of C1-6 haloalkyl, halogen, hydroxy, amino, and C1-6 alkoxy； Y4c is C3-8 cycloalkyl, optionally substituted with one or
