JAROSKOVA, LIBUSE,贾诺可,賈諾可,LINDERS, JOANNES THEODORUS MARIA,林德斯,BUYCK, CHRISTOPHE FRANCIS ROBERT NESTOR,布克,VAN DER VEKEN, LOUIS JOZEF ELISABETH,樊德肯
申请号：
TW094114610
公开号：
TWI357896B
申请日:
2005.05.06
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1 or 2； M represents a direct bond or a C1-3alkyl linker optionally substituted with one or two substituents selected from C1-4alkyl, C1-3alkyloxy-C1-4alkyl-, hydroxy-C1-4alkyl-, hydroxy, C1-3alkyloxy- or phenyl-C1-4alkyl-； R1 and R2 each independently represent hydrogen, halo, cyano, hydroxy, C1-4alkyl optionally substituted with halo, C1-4alkyloxy-optionally substituted with one or where possible two or three substituents selected from hydroxy, Ar1 and halo； R3 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-, cyano or hydroxy； R4 represents hydrogen, halo, C1-4alkyl, hydroxy, cyano or C1-4alkyloxy-optionally substituted with one or where possible two or three substituents selected from hydroxy and halo； R5 represents hydrogen, C1-4alkyl or Ar2&mdash；C1-4alkyl-； R6 represents hydrogen, hydroxy, halo, C1-4alkyl or C1-4alkyoxy-； R7 represents hydrogen or R7 and R5 taken together with the carbon atom to which they are attached from a &mdash；C2-alkyl-linker； Ar1 and Ar2 each independently represent phenyl or naphtyl wherein said phenyl and naphtyl are optionally substituted with C1-4alkyl, C1-4alkyloxy-, or phenyl-C1-4alkyl.其N－氧化物形式、醫藥可接受之加成鹽類及立體化學異構形式，其中n是1或2；M代表一個直接鍵結或C1－3烷基聯結，視情況以一或兩個選自C1－4烷基、C1－3烷基氧基－C1－4烷基－、羥基－C1－4烷基－、羥基、C1－3烷基氧基－或苯基－C1－4烷基的取代基取代；R1及R2各獨立代表氫、鹵基、氰基、羥基、視情況鹵基取代之C1－4烷基、C1－4烷基氧基－，視情況以一個或可能處兩或三個選自羥基、Ar1及鹵基的取代基取代；R3代表氫、鹵基、C1－4烷基、C1－4烷基氧基－、氰基或羥基；R4代表氫、鹵基、C1－4烷基、羥基、氰基或C1－4烷基氧基－，視情況以一個或可能處兩或三個選自羥基及鹵基的取代基取代；R5代表氫、C1－4烷基或Ar2－C1－4烷基－；R6代表氫、羥基、鹵基、C1－4烷基或C1－4烷基氧基－；R7代表氫、或R7及R5與附於其上之碳原子一起形成一個－C2－烷基聯結；Ar1及Ar2各獨立代表苯基或萘基，其中該苯基及萘基視情況以C1－4烷基、C1－4烷基氧基－或苯基C1－4烷基取代。
