Libuse Jaroskova;Christophe Francis Robert Nestor Buyck;Louis Jozef Elisabeth Van Der Veken;Vladimir Dimtchev Dimitrov;Joannes Theodorus Maria Linders;Theo Teofanov Nikiforov
发明人:
Libuse Jaroskova,Joannes Theodorus Maria Linders,Christophe Francis Robert Nestor Buyck,Louis Jozef Elisabeth Van Der Veken,Vladimir Dimtchev Dimitrov,Theo Teofanov Nikiforov
申请号：
US11632675
公开号：
US09012494B2
申请日:
2005.04.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, whereinn is 1 or 2；L represents a C1-3alkyl linker optionally substituted with one or two substituents selected from C1-4alkyl, C1-3alkyloxy-C1-4alkyl-, hydroxy-C1-4alkyl, hydroxy, C1-3alkyloxy- or phenyl-C1-4alkyl；M represents a direct bond or a C1-3alkyl linker optionally substituted with one or two substituents selected from hydroxy, C1-4alkyl or C1-4alkyloxy；R1 and R2 each independently represent hydrogen, halo, cyano, hydroxy, C1-4alkyl optionally substituted with halo,C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy, Ar1 and halo；or R1 and R2 taken together with the phenyl ring to which they are attached form naphtyl or 1,3-benzodioxolyl, wherein said naphtyl or 1,3-benzodioxolyl are optionally substituted with halo；R3 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-, cyano or hydroxy；R4 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-, cyano or hydroxy；R5 represents hydrogen, C1-4alkyl or Ar2-C1-4alky-；R6 represents hydrogen, halo, C1-4alkyl or C1-4alkyoxy-；Ar1 and Ar2 each independently represent phenyl or naphtyl wherein said phenyl and naphtyl are optionally substituted with C1-4alkyl, C1-4alkyloxy-, or phenyl-C1-4alkyl；for use as a medicine.
