DIELS, Gaston Stanislas Marcella,TEN HOLTE, Peter,FREYNE, Eddy Jean Edgard,GRAND-PERRET, Thierry Andre Regis,VAN EMELEN, Kristof,EMBRECHTS, Werner Constant Johan,BONNET, Pascal Ghislain André
申请号：
ES08775359
公开号：
ES2562218T3
申请日:
2008.07.25
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of the formula: ** Formula ** N-oxide forms, pharmaceutically acceptable addition salts, quaternary amines and stereochemically isomeric forms thereof, in which Y represents -C1-6-NR3 alkyl C 1-6 alkyl-； -C 1-6 alkyl-CO-Het 1 -C 1-6 alkyl-； -C1-6 alkyl-Het2-CO-NR4-C1-6 alkyl； or -C1-6-NR3-CO-C1-6-NR4-CO-C1-6 alkyl alkyl； in which each -C1-6 alkyl- in any of -C1-6-NR3-CO-C1-6 alkyl； -C 1-6 alkyl-CO-Het 1 -C 1-6 alkyl； -C1-6-Het2-CO-NR4-C1-6 alkyl； or -C1-6-NR3-CO-alkyl of C1-6-NR4-CO-C1-6 alkyl is optionally and independently substituted with a substituent selected from hydroxy, phenyl or Het3； X1 represents a direct link, -O-； -NR5- or -C 1-4 alkyl-NR6-, in which the rest of -C 1-4 alkyl- is directly attached to the phenyl ring； X2 represents a direct bond or -C 1-4 alkyl-NR7-, in which the rest of -C 1-4 alkyl is directly attached to the pyrrolopidimidine ring system Q represents hydrogen, halogen, C 1-6 alkyl, cycloalkyl C3-6, Het5, -NR9R10, C1-4-O- alkyl, C3-6-O- cycloalkyl, Het6-O-, Ar1-O, C1-4-S alkyl (O) 1-2 -, C3-6-S (O) 1-2- cycloalkyl, Het7-S (O) 1-2-, Ar2- S (O) 1-2, C1-4-S- alkyl or C3 cycloalkyl -6-S-； R1 and R2 each independently represent hydrogen； halo； hydroxy； C1-6 alkyl； C3-6 cycloalkyl； C1-4-O- alkyl； C3-6-O- cycloalkyl； Het4； cyano； C1-6 alkyl substituted with one or, where possible, two, three or more substituents selected from halo, hydroxy or C1-4-O- alkyl； C1-4-O- alkyl substituted with one or, where possible, two, three or more substituents selected from halo, hydroxy, C1-4-O- alkyl, C1-4-O-C1- alkyl 4-O-, phenyl, C3-6 cycloalkyl, C3-6-O- cycloalkyl, C3-6-NH-CO- cycloalkyl, Het8-O-, Het9-CO-, Ar3-O-, Ar6- S-, HetAr1-S-, thiazolyl-NR11-, pyridinyl-NR12-, pyrazinyl-NH-, C1-4-O-alkyl C1-4-NR13-, Ar7-NH-, HetAr2-NH-； C3-6-O- cycloalkyl substituted with one or, where possible, two, three or more substituents selected from halo, hydroxy or C1-4-O- alkyl； piranil-O-； tetrahydrofuran-O-； Ar8-NH-CONH-； C1-6-NH-CO-NH- alkyl； C3-6-NH-CO-NH-
