HANS HANSEN,LYNN HAWKINS,SALLY ISHIZAKA,SHAWN SCHILLER,ERIC CARLSON,CHIKAKO OGAWA,MATTHEW MACKEY,HEATHER DAVIS
申请号：
ARP140103811
公开号：
AR098014A1
申请日:
2014.10.14
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Quinine compounds, as antagonists or inhibitors of receptors such as methanol 7 and / or 8, are selectively substituted and used in the synthesis of effective drugs for the treatment of systemic lupus erythematosus (SLE) and lupus nephritis, in which methanol is a protein of innate immune system. 1. Requirement 1: a compound (1) with formula characteristics,where at least one of R¹ and R² is -H, methyl, or ethyl, and the other is -H； or the other is C₁₋₆ alkyl which is optionally substituted with: -OH, methoxy, ethoxy, -OCH (CH () ₂,-O (CH) CHPhenyl, furan-o (ch832222)； phenyl, methyltetraethyl-f-n (ch832323) c833222；Cyanogen, pyridinedioxy, fluoronoxyl, isochrome, phenol, benzene, benzeneOxo...a. Amino acid, carbamate, 7-member helix, 3-6-member cyclopentadiene, saturated or unsaturated, or unsaturated or unsaturated, optionally including one or more heteroatoms selected from O and N, optionally replacing one or more C or N atoms with methyl, cyanogen, fluorine, methylamine or trifluoride, or c83318327cyclo； Saturated or unsaturated, or unsaturated, optionally including one or more heteroatoms selected from O, s, and N, optionally replacing one or more C or N atoms with methyl, ethyl, pyridine, azidine, acrylamide, aminomethylamine, carbamate, or trifluoromethyl； or R1 and R2,Together with the nitrogen atoms connected to them, they form 8 to 11 members of spirulina, an 8-member bike, a 7-member spirulina, an optional glycol substitute, or a 4 to 6-member cyclopentanediol substitute, but at least one anthrax substitute can be used, 1. Carbamate, methyl (ethylamine) methyl (dimethylamine) methyl, dimethylamine (methylamine) methyl and amino, wherein R3 cubic meter is - H or methyl； 6. Claim 6: a compound classified as formula (2), wherein r8308es-h or methyl； r8330925 is saturated, partially saturated or unsaturated tar；Optionally, change to: - H, - Cl, - F, - Oh, - nh832222,Oxo...-N (CH CH)Phenyl, cyclohexadiene, methyl phenyl tricarboxylate, cyclohexadiene acryloni
