BUSH, JULIE KAY,FUL, MARGARET MARY,REUTZEL-EDENS, SUSAN MARIE
申请号：
HRP20050035
公开号：
HRP20050035B1
申请日:
2005.01.12
申请国别(地区):
HR
年份:
2013
代理人:
摘要：
Thienyl-glycoside compounds (I) are new. Thienyl-glycoside compounds of formula (I) and their salts are new. [Image] R 1, R 2H, halo, OH, NO 2, CN, COOH, COT', COOT', CONH 2, CONHT', CONT' 2, T', 2-6C alkenyl, 2-6C alkynyl, OT', -T'-OH, -T'-OT', Ph,CH 2Ph, (1-4C) alkylcarbonyl (optionally substituted (os) by one or more F), SO 2NH 2, SO 2NHT, SO 2NT 2, ST, S(CH 2) pPh', SOT, SO(CH 2) pPh', SO 2T, SO 2(CH 2) pPh', NH 2, NHT, NT 2, 1-7C acylamino, Ph'' or -O(CH 2) pPh''； T : 1-6C alkyl； T' : 1-6C alkyl (os by one or more F)； p : 0-6； Ph' : phenyl (os by 1 or 2 of F, Cl, Br, OH, CF 3, NO 2, CN, OCF 3, OT, T or NH 2)； Ph'' : phenyl (os by 1-3 of halo, OH, CF 3, NO 2, CN, OCF 3, OT, T, NH 2, NHT, NT 2, SO 2Me, COOH, COOT or CONH 2)； A : direct bond or 1-15C alkanediyl (optionally having one or more C-atom(s) replaced by O, CO, CH=CH, CC, S, CH(OH), CHF, SO, SO 2, N(T), N(-T-Ph) or NH)； n : 0-4； Cyc 1>；3-7 membered saturated, partially unsaturated or unsaturated ring, optionally having one C-atom replaced by O or S； R 3 - R 5H, halo, OH, NO 2, CN, COOH, COOT', (1-4C) alkylcarbonyl (os by one or more F), CONH 2, CONHT', CONT' 2, T', 2-6C alkenyl, 2-6C alkynyl, 1-12C alkoxy (os by one or more F), -T'-OH, -T'-OT', Ph,CH 2Ph, SO 2NH 2, SO 2NHT, SO 2NT 2, ST, S(CH 2) pPh', SOT, SO(CH 2) pPh', SO 2T, SO 2(CH 2) pPh', NH 2, NHT, NT 2, 1-7C acylamino, Ph'', -(CH 2) pPh'' or -O(CH 2) pPh''； or R 3 + R 4group completing a 5-7 membered saturated, partially unsaturated or unsaturated ring (Cyc 2>；), optionally having 1 or 2 C-atom(s) replaced by N, O or S and os by T, 2-5C alkenyl or 2-5C (all optionally having one CH 2 replaced by O) or by F, Cl, OH, CF 3, NO 2, CN, (1-4C) alkoxycarbonyl, CONH 2, (1-4C) alkylaminocarbonyl or OCF 3； and provided that when R 3 and R 4 form a ring, R 5 is H. ACTIVITY : Antidiabetic； nephrotropic； ophthalmological； neuroprotective； anorectic； cardiant； vasotropic； thrombolytic； anticoagulant； antiarteriosclerotic； antiinflammatory； immunosuppressive
