3 - ((straight) aril) - 8-amine-2-oxo-1, 3-diaza-helix - [4.5] - Dean, phase and use in medicine, especially in pain treatment 1. Property 1: compound (1) with general formula property,R¹ and R² independently of each other mean -H； -C₁₋₆-alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently selected from each other from the group consisting of -F, -Cl, -Br, - I, -OH, -OCH₃,-CN and -CO₂CH₃；a. A 3-12 person, saturated or unsaturated, unsaturated or unsaturated circulating chemical device, not replaced or replaced by one, two, three or four substitutes independently selected from a group consisting of - F, - Cl, - Br, - I, - Oh, - och-8323；-CN and -CO₂CH₃；a. 3-12 members of the bicycle unit can be selected through - c833213126 - asphalt connection；a. A nonreplaced linear or treelike, saturated or unsaturated, or unsaturated, or unsaturated, or unsaturated, or unsaturated, 3-12 member heterocyclic chemical device, which is not replaced or replaced by one, two, three or four substitutes independently selected from the group consisting of F, Cl, Br, I, oh, oc832323；-CN and -CO₂CH₃；wherein said 3-12 membered heterocycloalkyl unit is optionally connected through -C₁₋₆-alkylene-,linear or branched, saturated or unsaturated, unsubstituted； or R¹ and R² together with the nitrogen atom to which they are attached form a ring and mean - (CH₂) ₃₋₆-；- (CH) -O- (CH) -o - (CH) -NRA- (CH) -where RA means -H or -C₁₋₆-alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently selected from each other from the group consisting of -F, - Cl, -Br and -I； R³ means -C₁₋₆-alkyl, linear or branched, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted； a 3-12 membered cycloalkyl unit, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted； wherein said 3-12 membered cycloalkyl unit is option
