COMPOSES DE TRIAZINE PYRROLE SUBSTITUES EN POSITION 7 OU SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CEUX-CI, LEUR PROCEDE DE PREPARATION ET LEURS UTILISATIONS
The present invention relates to 7-site substituted pyrrole [2,1-f][1,2,4] triazine compounds or pharmaceutically acceptable salts thereof, and a preparation method therefor and uses thereof. This kind of compound shows good PI3K inhibition activity, can effectively inhibit the activity of the PI3K kinase； and due to the introduction of 7-site groups, bioavailability and other pharmacokinetic properties have been greatly improved. In addition, the compounds in the present invention show an unpredictable high selectivity and strong inhibitory activity on PI3kd, accordingly, the compounds can be used to treat diseases associated with PI3K pathways, especially for resisting against cancers or treatment of tumors, leukemia and autoimmune diseases. After further optimization and screening, the compounds are expected to develop into new antitumor drugs.
