Mutations of the PIK3CA gene in human cancers

• 收藏
• 分享

专利权人:

The Johns Hopkins University

发明人:

Yardena Samuels,Victor Velculescu,Kenneth Kinzler,Bert Vogelstein

申请号：

US15836366

公开号：

US10704105B2

申请日:

2017.12.08

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the PI3K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the PI3K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/