Yardena Samuels,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein
申请号：
US16853230
公开号：
US10787713B2
申请日:
2020.04.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the PI3K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the PI3K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target.
