Chinese Academy of Sciences;Shanghai Institute of Materia Medica
发明人:
YANG, Chunhao,MENG, Linghua,XIANG, Haoyue,LI, Jing,WANG, Xiang,TAN, Cun,HE, Qian,DING, Jian,CHEN, Yi
申请号：
AU2018287971
公开号：
AU2018287971A1
申请日:
2018.06.22
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention relates to 7-site substituted pyrrole [2,1-f][1,2,4] triazine compounds or pharmaceutically acceptable salts thereof, and a preparation method therefor and uses thereof. This kind of compound shows good PI3K inhibition activity, can effectively inhibit the activity of the PI3K kinase； and due to the introduction of 7-site groups, bioavailability and other pharmacokinetic properties have been greatly improved. In addition, the compounds in the present invention show an unpredictable high selectivity and strong inhibitory activity on PI3kδ, accordingly, the compounds can be used to treat diseases associated with PI3K pathways, especially for resisting against cancers or treatment of tumors, leukemia and autoimmune diseases. After further optimization and screening, the compounds are expected to develop into new antitumor drugs.
