It has been found that the compounds of formula (1) Act as antagonists or inverse agonists of glucagon. Accordingly, the compounds of formula (1) and Pharmaceutical compositions thereof are useful for treating diseases, Disorders or conditions mediated by glucag NG.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt thereof, wherein R1 is a heteroaryl Group of 5 members joined through a carbon Atom or a nitrogen Atom and is optionally with a condensate cycloalkyl C4 - 7A phenyl or heteroaryl heteroaryl Member 6, and 5 members optionally substituted with one to four substituents selected each independently between Halo - S (o) 2 - alkyl - 3 - S - C1, C1 - 3 hydroxyl, alkyl, - C (o) nrarb cycloalkyl, c3-5, Cyano phenyl is OPC Ionalmente replaced with one to three Halo, cyano, c1-3 alkyl or alkoxy c1-3,Heteroaryl of 6 members that is optionally substituted with one to three Halo, cyano, c1-3 alkyl or alkoxy c1-3 alkyl, optionally substituted C1 - 6 with one to three Fluorine, or C1 6 - alkoxy optionally substituted with one to three Fluorine； ra and RB are each independently c1-3 alkyl or H R； 2 h or Methyl； R3 is tetrazolilo, tetrazolilo - CH2 -, - (CH2) 2so3h or 2co2h, - (CH2)- ch2chfco2h or - ch2chohco2h； A1, A2, A3 and A4 are each independently CR4 or n, provided that no more than two from A1, A2, A3 and A4 are n； R4 is independently at each occurrence Halo h, alkyl, cyano, c1-3 optionally substituted with one to three Fluorine, alkoxy or c1-3 option Now replaced with one to three Fluorine； L - X (R5) - or - ch - ch (R5) - X - X is CH2,；O or NH； R5 C1 - 6 that is rented is optionally substituted with one to three fluoride, hydroxyl or cycloalkyl methoxy； C3 - 7 which is optionally substituted with one to two c1-3 alkyl which are optionally substituted with one to three fluoride and can be replaced by one to two carbons of the Ci Cloalquilo C3 - 7 by an NH, N - alkyl c1-3, o or s； or cicloalquil C1 - C3 alkyl - 7 6In the group of the cicloalquil
