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Development of dengue virus vaccine components
专利权人:
发明人:
申请号:
EP12182319.9
公开号:
EP2589602B1
申请日:
2007.08.15
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3 untranslated region (3-UTR) comprising a ”30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the ”30 mutation deleted from the 3-UTR that removes sequence in the 5 direction as far as the 5 boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3-UTR of a dengue virus of a first serotype with the 3-UTR of a dengue virus of a second serotype, optionally containing the ”30 mutation and nucleotides additional to the ”30 mutation deleted from the 3-UTR and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.
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