KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;JEIL PHARMACEUTICAL CO., LTD.;CJ CORP.
发明人:
CHEON, HYAE GYEONG,YOO, SUNG-EUN,KIM, SUNG SOO,YANG, SUNG-DON,KIM, KWANG-ROK,RHEE, SANG DAL,AHN, JIN HEE,KANG, SEUNG KYU,JUNG, WON HOON,PARK, SUNG DAE,KIM, NAM GEE,LEE, JANG HYUK,HUH, SUN CHUL,LEE, JA
申请号：
EP05733398
公开号：
EP1740531A4
申请日:
2005.04.13
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
An indene derivative for selectively modulating the activities of peroxisome proliferator activated receptors (PPARs) having the following formula (I): wherein, R1 is C1-6 alkyl, C1-6 alkenyl, or C3-6 cycloalkyl, each of which is unsubstituted or substituted with one or more phenyl groups； R2 is H, CN, CO2Ra, CH2CO2Ra, CONRbRc, or phenyl； R3 is C1-6 alkyl, C3-6 cycloalkyl, naphthyl, phenyl, being each unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, CN, NH2, NO2, ORa, phenyloxy, C1-6 alkyl, and C3-6 cycloalkyl； and R4, R5, R6, and R7 are each independently H, OH, OSO2CH3, O(CH2)mRe, CH2Rf, OCOCH2ORg, OCH2CH2ORg, OCH2CH&boxH；CHRg, or pyridine-2-yloxy, or R5 and R6 together form OCH2O.
