您的位置: 首页 > 农业专利 > 详情页

Benzothiazine derivatives, their preparation and application as drugs
专利权人:
PIERRE FABRE MÉDICAMENT
发明人:
PEREZ, MICHEL,LAMOTHE, MARIE,JUNQUERO, DIDIER,RIVAL, YVES
申请号:
ES10706624
公开号:
ES2483516T3
申请日:
2010.03.02
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compounds presenting the general formula (I): ** Formula ** in which: R1 represents: Hydrogen; C1-C6 alkyl; COR5; SO2R5; CO (CH2) mR6; CO (CH2) mOR6; (CH2) mR6; (CH2) mCONR7R8; (CH2) nNR7R8; (CH2) NOR6; CHR7OR9; (CH2) mR10 m represents: 1 to 6 n represents: 2 to 6 R2 represents: - a phenyl substituted with one or more groups selected from a halogen, C1-C6 alkyl, CN, OH, CF3, OCF3, SMe, COMe , CMe (OH) CF3, CH (OH) CF3, COOR7, CONR7R11; - a naphthyl, 1,2,3,4-tetrahydro-naphthalene, biphenyl, phenyl pyridine or a different indole heterocycle, in the case where R1, R4 and R'4 represent a hydrogen, either unsubstituted or substituted with one or more groups selected from a halogen or C1-C6 alkyl, CN, OH, CF3, OCF3, OMe, SMe; - a cycloalkyl, or unsubstituted or substituted with OH, CONH2, SO2Me, SO2NH2; with the proviso that: - the R2 group is always attached to the carbonyl through a carbon atom; - when R2 is a phenyl, the COOR7 substituent is never in position 4 in relation to carbonyl; R3 represents: methyl or ethyl; R4 and R'4, identical or different, represent: hydrogen; halogen; C1-C6 alkyl; CN; CF3; OCF3; SMe; OMe; NR7R8; SO2Me; R5 represents: C1-C6 alkyl; phenyl, or unsubstituted or substituted with one or more groups selected from halogen, C1-C6 alkyl, CN, OH, CF3, OCF3, SMe; a naphthyl, or unsubstituted or substituted with one or more groups selected from halogen or C1-C6 alkyl, CN, OH, CF3, OCF3, SMe; a cycloalkyl, either unsubstituted or substituted with a CONH2, SO2Me, SO2NH2; heteroaryl, or unsubstituted or substituted with one or more groups selected from halogen, C1-C6 alkyl, CN, OH, CF3, OCF3, SMe; R6 represents: hydrogen; C1-C6 alkyl; phenyl, or unsubstituted or substituted with one or more groups selected from halogen, C1-C6 alkyl, CN, OH, CF3, OCF3, SMe; a naphthyl or heterocycle, or unsubstituted or substituted with one or more groups selected from halogen or C1-C6 alkyl, CN, OH, CF3, OCF3, SMe; a cycloalkyl, or unsubstituted or substituted with CONH
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充