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1,6-diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
专利权人:
Wockhardt Limited
发明人:
PATEL, Mahesh Vithalbhai,DESHPANDE, Prasad Keshav,BHAWSAR, Satish,BHAGWAT, Sachin,JAFRI, Mohammad Alam,MISHRA, Amit,PAVASE, Laxmikant,GUPTA, Sunil,KALE, Rajesh,JOSHI, Sanjeev
申请号:
ES12772808
公开号:
ES2603198T3
申请日:
2012.08.24
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of Formula (I): ** Formula ** or a stereoisomer or a pharmaceutically acceptable salt thereof; wherein: R1 is: (a) hydrogen, (b) (CO) n-R3, (c) COOR4 or (d) COCH2COR3; n is 0, 1 or 2; R2 is: (a) SO3M, (b) SO2NH2, (c) PO3M, (d) CH2COOM, (e) CF2COOM, (f) CHFCOOM or (g) CF3; M is hydrogen or a cation; R3 is: (a) hydrogen, (b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR6R7, NR6R7, NR5COR8, NR5CONR6R7, heterocyclyl, heteroaryl, cycloalkyl or aryl, ( c) CN, (d) NR6R7, (e) CONR6R7, (f) NHCONR6R7, (g) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2- alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl or NHCONR6R7, (h) heterocyclyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2 -aryl, OSO2-alkyl, OSO2-aryl, NHC (NH) NR6R7 or NHCONR6R7, (i) heteroaryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2- alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl or NHCONR6R7, (j) cycloalkyl optionally It is substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl or NHCONR6R7, (k) alkyl substituted cycloalkyl C1-C6, wherein C1-C6 alkyl is further substituted with one or more substituents independently selected from OR5, NR6R7, halogen, CN or CONR6R7 or (1) OR8; R4 is: (a) hydrogen, (b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR6R7, NR6R7, NR5COR8, heterocyclyl, heteroaryl, cycloalkyl or aryl, (c) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl or NHCONR6R7
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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