LUBRIKS DIMITRIJS,PRIEPKE HENNING,SUNA EDGARS,KUELZER RAIMUND,STENKAMP DIRK,DOODS HENRI,ROENN ROBERT,PELCMAN BENJAMIN,PFAU ROLAND
申请号：
ARP110103038
公开号：
AR082509A1
申请日:
2011.08.19
申请国别(地区):
AR
年份:
2012
代理人:
摘要：
Their use as inhibitors of microsomal prostaglandin e2 synthase 1 (mpges-1), Pharmaceutical compositions containing them and their uses as Drugs for the treatment and Prevention of inflammatory diseases and / or associated conditions. A, M, W, R1, R2 and R6, R7 have the meanings given in the description.Claim 1: a compound characterized by the formula (1) wherein R1 represents alkyl, Halo, c1-3 alkyl group, where the latter is optionally substituted with one or more Fluorine Atoms； R2 represents Hydrogen, alkyl, Halo, c1-3 alkyl group and, where the latter It is optionally substituted with one or more Fluorine Atoms； W represents - C (o) -, - C (o) o -,Where these groups are attached to the nitrogen of the rest - NH - through the carbon Atom； M represents cycloalkyl alkyl C1 - C3 - 6, - 7, where the two groups are optionally substituted with one or more selected groups of - F, - Oh, - NH2, - CN, - NH (alkyl C1 2 - (alkyl) - n C1 - 2, - 2) Alkyl c1-3 alkyl, cycloalkyl C1 - C3 - 5 - 4Where in these last three groups are optionally substituted alkyl or cycloalkyl groups with one or more Fluorine Atoms； or Oxetanil tetrahidrofuranil tetrahidropiranil -, -, -, azetidinil pirrolidinil piperidinil -, -, -, being all these groups are optionally substituted with one or more Fluorine substituents selected from alkyl, - CN, - C1 - 3Where the alkyl group is optionally substituted with one or more Fluorine Atoms； or phenyl, pyridyl, pirrolil, Thienyl, thiazolyl imidazolyl pirazolil -, -, -, - or - oxazolil, isoxazolil, being all these groups are optionally substituted with one or more substituents selected ent Re - Halo, cn or c1-3 alkyl,Where the alkyl group is also optionally substituted with one or more Fluorine Atoms； R6 represents h, alkyl c1-5 alkyl, cycloalkyl - C0 - 2 - C3 - 5, where in the latter two groups are optionally substituted alkyl or cycloalkyl Fragments with one or more Fluorine Atoms； R7 represents c1-5 alkyl - or - C3 - 7, cicloalquil C0 - 2 - alkyl - or -H
