The present invention belongs to field of medicine and chemical technology, closes a kind of sterol derivative of what, preparation method and the usage. Specifically, compound or its pharmaceutically acceptable salt shown in what Formulas I are closed in system of the present invention, wherein R1 system is selected from-OH ,=O, H and C1-C3 alkyl； R2 system is selected from-OH, H and C1-C3 alkyl； R3 system is selected from-OH ,=O, H and C1-C3 alkyl； R4 system is selected from-OH, H and C1-C3 alkyl； And any 0,1,2,3 or 4 in R1, R2, R3 and R4 is-OH. The compounds of this invention can effectively inhibit HMG-CoA reductase, tumour cell and lipase, have the potentiality as reduction, antitumor or weight-reducing drug.本發明屬於醫藥化工領域，係關於一種甾醇類衍生物、其製備方法及用途。具體而言，本發明係關於式I所示之化合物，或其醫藥學上可接受之鹽，其中，R1係選自-OH、=O、H以及C1-C3烷基；R2係選自-OH、H以及C1-C3烷基；R3係選自-OH、=O、H以及C1-C3烷基；R4係選自-OH、H以及C1-C3烷基；且R1、R2、R3及R4中之任意0個、1個、2個、3個或4個為-OH。本發明化合物能夠有效地抑制HMG-CoA還原酶、腫瘤細胞以及脂肪酶，具有作為降低、抗腫瘤、或者減肥之藥物的潛力。
