BAGAL, SHARANJEET KAUR,BROWN, ALAN DANIEL,KEMP, MARK IAN,KLUTE, WOLFGANG,MARRON, BRIAN EDWARD,MILLER, DUNCAN CHARLES,SKERRATT, SARAH ELIZABETH,SUTO, MARK J.,WEST, CHRISTOPHER WILLIAM,MALET SANZ, LAIA
申请号：
ES13708908
公开号：
ES2548228T3
申请日:
2013.01.22
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I) ** Formula ** or a tautomer thereof, or a pharmaceutically acceptable salt or solvate of said compound or said tautomer, wherein: one of X and Y is C and the other is N； R1 is selected from H, F, Cl and CF3； one of R2 and R3 is selected from (C3-C6) alkyl, (C3-C6) cycloalkyl, adamantyl, and -CN substituted phenyl, and optionally further substituted with one or two groups independently selected from -F, -Cl , -CF3 and -CN； and the other of R2 and R3 is selected from H and F； R4 is selected from H, F, Cl and CF3 R5 is selected from (C1-C6) alkyl, (C1-C6) alkyl substituted with a group selected from - CONH2, - CONH-(C1-C3) alkyl, - CON ( (C1-C3) alkyl) in which the (C1-C3) alkyl groups may be the same or different, - OH, - (C1-C3) alkyl, and - OCONH2, (C3-C6) cycloalkyl, and phenyl , R6 is selected from H and (C1-C3) alkyl, or R5 and R6 together with the carbon atom to which they are attached can form a 3 to 6 membered cycloalkyl moiety that may be optionally condensed with benzo； R7 is H or methyl, or, when R5 and R6 do not form a cycloalkyl or cycloalkyl residue fused with benzo, R5 and R7 together with the carbon and nitrogen atoms to which they are attached can form monocyclic saturated nitrogen heterocycle of 4 to 6 members or bicyclic 6 to 8 members which may be optionally substituted with 1 or 2 groups selected from -C1-C3 alkyl, -OH and -F.Un compuesto de fórmula (I)**Fórmula** o un tautómero del mismo, o una sal o solvato farmacéuticamente aceptable de dicho compuesto o dicho tautómero, en la que: uno de X e Y es C y el otro es N； R1 se selecciona entre H, F, Cl y CF3； uno de R2 y R3 se selecciona entre alquilo (C3-C6), cicloalquilo (C3-C6), adamantilo, y fenilo sustituido con -CN, y opcionalmente sustituido de forma adicional con uno o dos grupos seleccionados independientemente entre -F, -Cl, -CF3 y -CN； y el otro de R2 y R3 se selecciona entre H y F； R4 se selecciona entre H, F, Cl y CF3 R5 se selecciona entre alquilo (C1 - C6), al
