BURGEY, CHRISTOPHER S.,DENG, ZHENGWU J.,NGUYEN, DIEM N.,PAONE, DANIEL V.,SHAW, ANTHONY W.,GINETTI, ANTHONY
申请号：
ES09824018
公开号：
ES2534199T3
申请日:
2009.10.21
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of structural formula I: ** Formula ** or pharmaceutically acceptable salts and individual enantiomers and diastereomers thereof in which: X is N or CH； W and Z independently, are absent or represent C (R2) 2, -O-, NR2, CO or SO0-2； R1 represents H, C1-6 alkyl, halogen, (CH2) nCF3, C3-10 cycloalkyl, C (R2) 2OH, -O-, CN, (CH2) nOR210, (CH2) n C5-10 heterocyclic, aryl (CH2 ) nC6-10 or C1-6 alkoxy； said alkyl, cycloalkyl, heterocyclyl and aryl being optionally substituted with 1 to 3 C1-6 alkyl groups, halogen, hydroxyl, (CH2) nCF3 or CN； R2 represents H, C1-6 alkyl, CF3, OH, CHF2 or CH2F； R3 represents CR2R4R5； one of R4 and R5 is C1-6 alkyl or hydrogen and the other is (CH2) C6-10 naryl or (CH2) C6-10 nheterocyclyl, said alkyl, aryl and heterocyclyl being optionally substituted with 1 to 3 groups of Ra, in wherein said aryl and heterocyclyl are (CH2) n phenyl, (CH2) npyridyl, (CH2) npyrimidinyl, (CH2) ntriazolyl, pyrazinyl or (CH2) noxadiazolyl； R6 represents hydrogen, OR2, -O-, CF3, C (R2) 2OR2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, (CH2) C6-10 naryl, (CH2) nheterocyclyl C5-10, said alkyl, aryl and heterocyclyl being optionally substituted with 1 to 3 groups of Ra20； Ra represents C1-6 alkyl, halogen, hydroxyl, OR2 (CH2) nCF3, -O-, C3-6 cycloalkyl, NR2C (O) R2, C (O) N (R2) 2, C (R2) 2OR2, C ( O) R2 NO2, CN, N (R2) 2, C (O) OR2, SO2R2, OR2, (CH2) C5-10 nheterocyclyl or (CH2) C6-10 naryl, said heterocyclyl and aryl being optionally substituted with 1 to 3 C1-6 alkyl, halogen, hydroxyl, (CH2) nCF3 or CN groups； and n represents from 0 to 4.Un compuesto de la fórmula estructural I:**Fórmula** o sales farmacéuticamente aceptables y enantiómeros y diastereómeros individuales de los mismos en la que: X es N o CH； W y Z independientemente, están ausentes o representan C(R2)2, -O-, NR2, CO o SO0-2； R1 representa H, alquilo C1-6, halógeno, (CH2)nCF3, cicloalquilo C3-10, C(R2)2OH, -O-, CN, (CH2)nOR210 , (CH2)n heterocíclico C5-10, arilo (CH2)nC6
