BARRETT, STEPHEN DOUGLAS,CHEN, HUIFEN,BOYS, MARK LAURENCE,KRAMER, JAMES B.
申请号：
ES07825309
公开号：
ES2435430T3
申请日:
2007.10.04
申请国别(地区):
ES
年份:
2013
代理人:
摘要：
A compound of formula I ** ** Formula or a pharmaceutically acceptable salt thereof, wherein: R1 is a thieno [3,2-c] pyridyl, a thieno [3,2-b] pyridyl, a thieno [2,3 -c] pyridinyl, or a thieno [2,3-b] pyridinyl, each delos which may be optionally substituted with one to three substituents each of formaindependiente the group consisting of: C1-C3 alkyl, - (alk -C1-C3) -S- (C1-C3 alkyl), -S-C1-C3 alkyl, - (C1-C3 alkyl) -O- (C1-C3 alkyl), -O-alkyl-C1 -C3, -C (O) O-alkyl C1-C3, -C (O) OH, -C (O) nR30R31, halo, -CN, -OH, where R30 and R31se independently selected from the group consisting : H, alkyl-C1-C3-OH, C1-C3 alkyl, halo and -OC-C1-C3 R2 and R3 are selected independently from the group consisting of: hydrogen, C1-C3 alkyl, - (C1-C3 alkyl) -S- (C1-C3 alkyl), -S-C1-C3 alkyl, - (C1-C3 alkyl) -O- (C1-C3 alkyl), -O-C1-C3 alkyl, -C (O) O-alkyl C1-C3, -C (O) OH, -C ( O) nR30R31, halo, -CN, -OH, and a C3-C6 cycloalkyl, wherein R30 and R31 are selected independently theGroup consisting of: H and alkyl-C1-C3 or R2 and R3 may be taken together to form a 5- or 6-membered, phenyl, cycloalkyl or C4-C6 heterocycloalkyl 4-6 membered, wherein said cycloalkyl or C4-C6 heterocycloalkyl miembrospueden be substituted 4-6 optionally with one to three substituents chosen independienteentre halo, -OH, oxo and C1-C3 alkyl, wherein said 5- or 6-membered, or phenyl, may be sustituidosopcionalmente with one to three substituents independently selected from halo , -CN, -OH, -O20alquil-C1-C3 and C1-C3 alkyl and R4, R5, R6 and R7 are selected from the group consisting of: H, -OH, C3-cycloalkyl, C1-C3 alkyl, - (C1-C3 alkyl) -S- (C1-C3 alkyl), - S-C1-C3 alkyl, - (C1-C3 alkyl) -O- (C1-C3 alkyl), -O-C1-C3 alkyl, -C (O) O-alkyl C1-C3, - C (O) OH, -C (O) nR30R31, halo, -CN, and -OH, wherein R30 and R31 are selected independently from the group consisting of: H, C1-C3 alkyl-O-alkyl-C1 -C3 and halo.Un compuesto de fórmula I**Fórmula** o una sal farmacéuticamente aceptable del mismo, donde: R1 es un tien
