Unwalla Rayomand Jal,Brown Matthew Frank,Fenwick Ashley Edward,Flanagan Mark Edward,Gonzales Andrea,Johnson Timothy Allan,Kaila Neelu,Mitton-Fry Mark J.,Strohbach Joseph Walter,Tenbrink Ruth E.,Trzupe
申请号：
NZ71041114
公开号：
NZ710411A
申请日:
2014.02.11
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
The present invention provides pharmaceutically active pyrrolo{ 2,3-d} pyrimidine compounds. Such compounds are useful for inhibiting Janus Kinase (JAK). The invention is also directed to compositions comprising the compositions of the invention and uses of the compositions in the treatment or prevention of disorders or conditions mediated by JAK. In particular, the present invention provides a compound of formula IA or a pharmaceutically acceptable salt thereof, wherein Y is –A-R5, where A is a bond, --(CH2)k-- or --(CD2)k-- and R5 is C1-C6 linear or branched chain alkyl, C3-C6 cycloalkyl, aryl, or --NRa’Rb’, or is an unsaturated, saturated or partially saturated monocyclic or bicyclic ring structure containing a total of five to eleven atoms having one to three heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur, wherein said alkyl, C3-C6 cycloalkyl, aryl, or monocyclic or bicyclic ring structure is further optionally substituted with one or more substituents selected from the group consisting of deuterium, halo, C1-C6 linear or branched chain alkyl, CN, hydroxyl, CF3, --ORe, --NReRf, --S(O)pRe and C3-C6 cycloalkyl, where said alkyl and cycloalkyl may be optionally substituted with one or more substituents selected from the group consisting of halo, CN, hydroxyl, CONH2, and SO2CH3, where (a) Ra’ and Rb’ are independently hydrogen, deuterium, C1-C6 linear or branched chain alkyl, C3-C6 cycloalkyl, aryl, (C1-C6 linear or branched chain alkyl)aryl, heteroaryl, or (C1-C6 linear or branched chain alkyl)heteroaryl, where said alkyl and cycloalkyl may be optionally substituted with one or more Rc’, or (b) Ra’ and Rb’ together form a chain comprising -–(CRc’Rd’)j--, where Rc’ and Rd’ are independently hydrogen, deuterium, C1-C6 linear or branched chain alkyl, aryl, (C1-C6 linear or branched chain alkyl)aryl, heteroaryl, (C1-C6 linear or branched chain alkyl)heteroaryl, halo, CN, hydroxyl, CF3, CONH2, --ORe, --NReRf, or --S(O)pRe； w
