Beccari, Andrea Rosario,Bianchini, Gianluca,Fani', Michela,Zippoli, Mara,Liberati, Chiara
申请号：
ES13172137
公开号：
ES2621085T3
申请日:
2013.06.14
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
The compound of formula (I): ** Formula ** and pharmaceutically acceptable salts thereof, wherein X and Y are different from each other and are O or NH； R1 is selected from the group consisting of C1-C6 alkyl； C3-C6 cycloalkyl and C1-C3 haloalkyl. R2 is selected from the group consisting of: - Ci-Cs alkyl； - C3-C6 cycloalkyl； - phenyl unsubstituted or substituted with at least one group selected from -O-C1-C4 alkyl and C1-C4 alkyl； - benzothiophene； - a 5- or 6-membered heteroaromatic ring selected from pyridine and pyrrole. R3 is selected from the group consisting of: - CrCs alkyl； - (CH2) mCOCH3l in which m is an integer between 1 and 4； - (CH2) nZ, in which n is an integer between 1 and 3, and Z is selected from the group consisting of dialkylamine, C3-C6 cycloalkyl, benzotriazole, isoindole-1,3 (2H) -dione- 2-yl, imidazole, triazole, indole, furan and phenyl, the latter being unsubstituted or substituted with one or more groups selected from halo, C1-C3 alkyl, O-C1-C3 alkyl and C1-C3 alkylamino； - C3-C6 cycloalkyl unsubstituted or substituted with one or more groups selected from halo and C1-C3 alkyl； - 2-methyl-1,3-oxazol-4-yl； - phenyl unsubstituted or substituted with one or more groups selected from Ci-C3 alkyl, hydroxyl, halo and nitro for use as a medicament.El compuesto de formula (I):**Fórmula** y sales farmaceuticamente aceptables del mismo, en la que X e Y son diferentes el uno del otro y son O o NH； R1 se selecciona entre el grupo que consiste en alquilo C1-C6； cicloalquilo C3-C6 y haloalquilo C1-C3. R2 se selecciona entre el grupo que consiste en: - alquilo Ci-Cs； - cicloalquilo C3-C6； - fenilo sin sustituir o sustituido con al menos un grupo seleccionado entre -O-alquilo C1-C4 y alquilo C1-C4； - benzotiofeno； - un anillo heteroaromatico de 5 o 6 miembros seleccionado entre piridina y pirrol. R3 se selecciona entre el grupo que consiste en: - alquilo CrCs； - (CH2)mCOCH3l en el que m es un numero entero comprendido entre 1 y 4； - (CH2)n-Z, en el que n
