CASAREZ, Anthony,FUREGATI, Markus,KOCH, Guido,LIN, Xiaodong,OSSOLA, Flavio,RECK, Folkert,SIMMONS, Robert Lowell
申请号：
PE2019000446
公开号：
PE20190459A1
申请日:
2017.09.28
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
The invention generally relates to a compound of formula (a).Or its salt or form is zwitternica, wherein R1 and R2 are independent substitutes selected from H and C1-C4 asphalt, replaced by up to three selected halo groups (CN, oxo, etc.)； Z is NR3 or n-or3； R3 is independently selected from h, cy and C1-C4 asphalt； C1-C4 asphalt can be replaced by up to three selected cy, halo, CN groups, CY, among other things, is a C3-C6 or 4-6 ring, consisting of one or two heterosexuals.which can be substituted with up to 3 groups selected from oxo, halo, alkyl, CN, among others； In addition to pharmaceutical compositions comprising these compounds together with pharmaceutically acceptable vehicles, which in turn are included within the pharmaceutical combinations together with a beta-lactam antibiotic, a third therapeutic agent (beta-lactam antibiotic, macrolide, tetracycline) may be added. among others) or an immunomodulator. It also refers to methods of preparation of the compounds and compositions,And the treatment of bacterial infections and diseases The current invention is useful for the treatment of infections caused by Gram negative bacteria, including drug-resistant strains.Esta invencion se refiere generalmente a compuestos de la Formula (A), o su sal o forma zwitterionica, donde R1 y R2 se seleccionan de forma independiente de H y alquilo C1-C4 opcionalmente sustituido por hasta 3 grupos seleccionados de halo, CN, oxo, entre otros； Z es NR3 o N-OR3； R3 se selecciona de forma independiente de H, Cy, y alquilo C1-C4 que puede sustituirse con hasta 3 grupos seleccionados de Cy, halo, CN, entre otros； Cy es un anillo de cicloalquilo C3-C6 o heterociclico de 4-6 miembros que contienen 1 o 2 heteroatomos (N, O o S), que se puede sustituir con hasta 3 grupos seleccionados de oxo, halo, alquilo, CN, entre otros； ademas de composiciones farmaceuticas que comprenden estos compuestos junto con vehiculos farmaceuticamente aceptables, los que a su vez estan comprendidos dentro d
