Azetidinil refers to compounds derived from phenyl, pyridyl or pirazinil carboxamide of formula (i) where X is n or CR4, where r is H, F, CL, CN, among others W is n or CR6, wherein R6 is H, F, alkyl (C1 - C3), among others and where is No CR7, R7 is H, CL - ch2cn, among others r1 is alkyl ( C1 - C6), cycloalkyl (C3 C6), heterocicloalquilo 4 to 6 members,Among others, R2 is H or alkyl (C1 - C3) R3 is H, F, - CN, ocf3, among others R5 is H, alkyl (C1 - C3) - o-alkyl (C1 - C3), among others.Preferred compounds are: 4 - (3 - (cyanomethyl) - 3 - [4 - (1h pyrrolo [2,3-b] pyridin-4-yl) - 1H pyrazol-1-yl] azetidin - il - 1} - n {- isopropilbenzamida 5 - 3 - (cyanomethyl) - 3 - [4 - (1h pyrrolo [2,3-b] pyridin-4-yl) - 1H pyrazol-1-yl] azetidin - il - 1} - N - [(1S) - 1-cyclopropylethyl] pyridine - 2 - carboxamide 4 - (3 - (cyanomethyl) - 3 - [4 - (7H - P Irrolo [23 - d] pyrimidin-4-yl) - 1H pyrazol-1-yl] azetidin - il - 1} - 3 - fluoro-n - isopropilbenzamida among others. It also relates to a Pharmaceutical composition. These compounds are inhibitors of Janus Kinase (JAK) being useful in the treatment of Multiple sclerosis, lupus, rheumatoid arthritis, atopic dermatitisSE REFIERE A COMPUESTOS DERIVADOS DE AZETIDINIL FENIL, PIRIDIL O PIRAZINIL CARBOXAMIDA DE FORMULA (I) DONDE X ES N O CR4, EN DONDE R4 ES H, F, Cl, CN, ENTRE OTROS W ES N O CR6, EN DONDE R6 ES H, F, ALQUILO(C1-C3), ENTRE OTROS Y ES N O CR7, EN DONDE R7 ES H, Cl, -CH2CN, ENTRE OTROS R1 ES ALQUILO(C1-C6), CICLOALQUILO(C3-C6), HETEROCICLOALQUILO DE 4 A 6 MIEMBROS, ENTRE OTROS R2 ES H O ALQUILO(C1-C3) R3 ES H, F, CN, -OCF3, ENTRE OTROS R5 ES H, ALQUILO(C1-C3), -O-ALQUILO(C1-C3), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-{3-(CIANOMETIL)-3-[4-(1H-PIRROLO[2,3-b]PIRIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-1-IL}-N-ISOPROPILBENZAMIDA 5-{3-(CIANOMETIL)-3-[4-(1H-PIRROLO[2,3-b]PIRIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-1-IL}-N-[(1S)-1-CICLOPROPILETIL]PIRIDINA-2-CARBOXAMIDA 4-{3-(CIANOMETIL)-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H
