Antiinflammatory and antiallergic compounds in the glucose cholesterol family, methods of preparing these compounds, pharmaceutical ingredients containing these compounds, and combinations and therapeutic uses of these compounds. More specifically, the glucococcus supplied comes from isoxazolidina. Require 1: a compound with common formula characteristics, wherein R1 is - (CH2) N-Z - (CH2) n rsque； - R4； n is 0, 1 or 2； n rsque； is 0, 1 or 2； Z is a simple combination, or from S -.- that is...-C (O) - y -NR3-R3 is selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, aryl, aryl-C1-6 alkyl and heteroaryl, which are optionally substituted with -CN； R4 is selected from the groups consisting of: H, halogen, -OH, -SH, -CN and -NR6R7； aryl-C 1-6 alkyl, C 1-6 alkyl sulfonyl, C 1-6 alkylcarbonyl, C 1-6 alkylcarboxyl, HO-C 1-6 alkylcarboxyl, C 1-6 alkyl and C 1-6 alkoxy, which are optionally substituted with oxo groups； C1-6 alkyl which may be optionally substituted with one or more substituents selected from the group consisting of halogen atoms, -CN, -OH, -NH2, -NO2, -CF3 and -SH； C2-6 alkynyl； C5-17 alkenylcarbonyl；and a monocyclic, bicyclic or tricyclic ring saturated or partially unsaturated or unsaturated, such as C3-8 cycloalkyl, aryl, C5-10 heterocycloalkyl or heteroaryl, optionally substituted with one or more halogen atoms or oxo groups； R6 and R7 are independently selected from the group consisting of H, C1-6 alkyl and C1-6 alkoxy； X and Y are independently H or halogen atoms； R2 is selected from the group consisting of: - (CH2) s-K-A- (CH2) t-W, - (CH2) s-K- (CH2) t-B-W, and - (CH2) s- (CHR5) -W； s is 0 or 1； t is 0 or 1； K is selected from the group consisting of: a group -CH = CH-,a. Arileno and abarileno, of which arileno and abarileno can be replaced by one or more independently selected groups from halogen, c1-6-oh, C1-6 and c1-6-halogen, and a is selected from the following groups: one alliance, one o-and one s-group；B sele
