Buck Institute for Research on Aging;Mayo Foundation for Medical Education and Research;Unity Biotechnology, Inc.
发明人:
Remi-Martin Laberge,James L. Kirkland,Tamar Tchkonia,Yi Zhu,Nathaniel David,Alain Philippe Vasserot,Darren J. Baker,Bennett G. Childs,Jan M. A. van Deursen
申请号：
US15981696
公开号：
US10517866B2
申请日:
2018.05.16
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis； idiopathic pulmonary fibrosis； chronic obstructive pulmonary disease； osteoarthritis； senescence-associated ophthalmic diseases and disorders； and senescence-associated dermatological diseases and disorders.
