Unity Biotechnology, Inc.;Buck Institute for Research on Aging;Mayo Foundation for Medical Education and Research;The Johns Hopkins University
发明人:
Remi-Martin Laberge,Judith Campisi,Albert Davalos,Marco Demaria,Nathaniel David,Alain Philippe Vasserot,James L. Kirkland,Tamar Tchkonia,Jennifer Elisseeff,Chaekyu Kim,Okhee Jeon,Yi Zhu
申请号：
US16508119
公开号：
US20190343832A1
申请日:
2019.07.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis； idiopathic pulmonary fibrosis； chronic obstructive pulmonary disease； osteoarthritis； senescence-associated ophthalmic diseases and disorders； and senescence-associated dermatological diseases and disorders.
