Unity Biotechnology, Inc.;Buck Institute for Research on Aging;Mayo Foundation for Medical Education and Research
发明人:
Jose Alberto Lopez-Dominguez,Remi-Martin Laberge,Judith Campisi,Albert Davalos,Marco Demaria,Nathaniel David,Alain Philippe Vasserot,Darren J. Baker,Bennett G. Childs,James L. Kirkland,Tamar Tchkonia
申请号：
US15742458
公开号：
US20180193458A1
申请日:
2016.07.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis； idiopathic pulmonary fibrosis； chronic obstructive pulmonary disease； osteoarthritis； senescence-associated ophthalmic diseases and disorders； and senescence-associated dermatological diseases and disorders. Also included herein are methods for extending lifespan.
