Buck Institute for Research on Aging;Unity Biotechnology, Inc.;Mayo Foundation for Medical Education and Research;The Johns Hopkins University
发明人:
Remi-Martin Laberge,Judith Campisi,Albert Davalos,Marco Demaria,Nathaniel David,Alain Philippe Vasserot,James L. Kirkland,Tamar Tchkonia,Jan M. A. van Deursen,Jennifer Elisseeff,Chaekyu Kim,Okhee Jeon
申请号：
US15114762
公开号：
US09993472B2
申请日:
2015.01.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis； idiopathic pulmonary fibrosis； chronic obstructive pulmonary disease； osteoarthritis； senescence-associated ophthalmic diseases and disorders； and senescence-associated dermatological diseases and disorders.
