Buck Institute for Research on Aging;Mayo Foundation for Medical Education and Research;Unity Biotechnology, Inc.
发明人:
Remi-Martin Laberge,Judith Campisi,Marco Demaria,Nathaniel David,Alain Philippe Vasserot,James L. Kirkland,Tamar Tchkonia,Yi Zhu,Darren J. Baker,Bennett G. Childs,Jan M. A. van Deursen
申请号:
US15956613
公开号:
US10478432B2
申请日:
2018.04.18
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.