Buck Institute for Research on Aging;Mayo Foundation for Medical Education and Research;The Johns Hopkins University;Unity Biotechnology, Inc.
发明人:
申请号:
EP19216214.7
公开号:
EP3669881A1
申请日:
2015.01.28
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.